ECM and ECM- like materials – Ideal biomaterials for applications in regenerative medicine and cancer therapy
Regenerative strategies such as stem cell-based therapies and tissue engineering applications are being developed with the aim to replace, remodel, regenerate or support damaged tissues and organs.
Biomaterial-Enhanced Cell and Drug Delivery: Lessons Learned in the Cardiac Field and Future Perspectives
Heart failure is a significant clinical issue. It is the cause of enormous healthcare costs worldwide and results in significant morbidity and mortality. Cardiac regenerative therapy has progressed considerably from clinical and preclinical studies delivering simple suspensions of cells, macromolecule, and small molecules to more advanced delivery methods utilizing biomaterial scaffolds as depots for localized targeted delivery to the damaged and ischemic myocardium.
A minimally invasive endocradial catheter for delivery of stem cells embedded in fast-gelling hyaluronic acid hydrogels
Main author: Dolan E., Kohutova L., O'Neill H., Prvada M., Sulakova R., Daro D., Braun N., Cooney G., Bllavia G., Straino S., Kavanagh L., Flanagan A., Kelly H., Daffy G., Mur
“Design and development of a minimally invasive endocardial delivery device for fast-gelling hyaluronic acid hydrogels for the treatment of myocardial infarction”
Main author: Eimear B. Dolan, Lenka Kohutova, Hugh O’Neill, Brenton L. Kavanagh, Dorothee Daro, Gerard Cooney, Helena Kelly, Bruce P. Murphy and Garry P. Duffy